Dec 28, 2018
Here is a summary of this episode:
- In patients with liver impairment, it is better to use drugs
that are metabolized by phase II enzymes or drugs that are not
metabolized by the liver at all.
- Patients with severe renal impairment may also have liver
impairment. Use ⅔ of the recommended dose.
- Benzodiazepines and Z-drugs are contraindicated in CO2
retainers and those with severe sleep apnea. Opiates are better
than benzodiazepines in patients with terminal breathlessness.