Difficult-to-Treat Depression: First, Second, and Third-Line Strategies

Jul 25, 2026

In this episode, we explore what to do when antidepressants aren't working. How do you systematically approach a patient who isn't getting better — and when do you switch versus augment? Dr. Sagar Parikh walks through CANMAT's evidence-based framework for difficult-to-treat depression.

Faculty: Sagar V. Parikh, M.D., F.R.C.P.C.
Host: Richard Seeber, M.D.

• Learn more about our memberships here
• Earn 1.25 CME: Rethinking Depression Treatment: An Update of CANMAT’s Guidelines
• Pharmacologic Management of Difficult-to-Treat Depression: First, Second, and Third Line Options